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  • Title: Accumulation of oxidative damage during replicative aging of the yeast Saccharomyces cerevisiae.
    Author: Grzelak A, Macierzyńska E, Bartosz G.
    Journal: Exp Gerontol; 2006 Sep; 41(9):813-8. PubMed ID: 16891074.
    Abstract:
    Comparison of senescent yeast obtained by the "baby machine" technique with 2-day-old stationary phase cells revealed decreased activities of glutathione reductase, glutathione S-transferase, glutathione peroxidase and alcohol dehydrogenase, reduction of total antioxidant capacity, protein glycation and accumulation of products of oxidative damage: protein carbonyls and DNA damage assessed by augmented content of 8-oxoguanine and increased tail momentum of cellular DNA in the comet assay. These results are consistent with a role for oxidative damage during replicative senescence of Saccharomyces cerevisiae.
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