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  • Title: PACAP inhibits oxidative stress-induced activation of MAP kinase-dependent apoptotic pathway in cultured cardiomyocytes.
    Author: Gasz B, Rácz B, Röth E, Borsiczky B, Tamás A, Boronkai A, Gallyas F, Tóth G, Reglodi D.
    Journal: Ann N Y Acad Sci; 2006 Jul; 1070():293-7. PubMed ID: 16891268.
    Abstract:
    The present article investigated the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on oxidative stress-induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal-regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP is able to attenuate oxidative stress-induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase-dependent apoptotic pathway.
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