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  • Title: Pharmacodynamics of dalbavancin studied in an in vitro pharmacokinetic system.
    Author: Bowker KE, Noel AR, MacGowan AP.
    Journal: J Antimicrob Chemother; 2006 Oct; 58(4):802-5. PubMed ID: 16891629.
    Abstract:
    OBJECTIVES: The antibacterial effect of dalbavancin was studied against Staphylococcus aureus using stepwise declining concentrations designed to model a range of free drug concentrations observed in human serum. METHODS: Initial concentrations ranged from 0.6 to 21 mg/L and experiments were conducted over 240 h. Three vancomycin-susceptible and one vancomycin-intermediate strain of S. aureus were used. RESULTS AND CONCLUSIONS: Dalbavancin showed non-concentration-dependent killing against the three vancomycin-susceptible strains in the range 3-21 mg/L and the vancomycin-intermediate strain at 15 and 21 mg/L. AUC/MIC could be related to antibacterial effect. The AUC/MIC for a bacteriostatic effect was 36 at 24 h, 55 at 120 h and 100 at 240 h. A larger AUC/MIC was required to produce a 2 log reduction in counts, being 214 at 24 h, 195 at 120 h and 331 at 240 h.
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