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  • Title: Treatment monitoring and response prediction with proton MR spectroscopy in AD.
    Author: Jessen F, Traeber F, Freymann K, Maier W, Schild HH, Block W.
    Journal: Neurology; 2006 Aug 08; 67(3):528-30. PubMed ID: 16894124.
    Abstract:
    In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.
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