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  • Title: Perioperative antibiotic prophylaxis: a critical review.
    Author: De Lalla F.
    Journal: Surg Infect (Larchmt); 2006; 7 Suppl 2():S37-9. PubMed ID: 16895502.
    Abstract:
    BACKGROUND: The value of perioperative prophylaxis is established for clean-contaminated procedures. For clean surgery, prophylaxis traditionally has been reserved for prosthetic device implantation procedures. METHODS: Review of pertinent English-language literature. CURRENT RECOMMENDATIONS: Evidence suggests that prophylactic antibiotics are advisable for at least some non-prosthetic procedures and that glycopeptides might have a role for major prosthetic surgery in units with a high prevalence of methicillin-resistant Staphylococcus aureus. In clean-contaminated surgery, cefazolin is recommended, although not for colorectal procedures or obstetric/gynecologic surgery that requires anti-anaerobic coverage. CONCLUSION: Antibiotic prophylaxis is generally overprescribed (i.e., given for too long). Short-duration prophylaxis is effective and safe.
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