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  • Title: Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging.
    Author: Li C, Greenwood TR, Bhujwalla ZM, Glunde K.
    Journal: Org Lett; 2006 Aug 17; 8(17):3623-6. PubMed ID: 16898776.
    Abstract:
    [structure: see text] Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.
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