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  • Title: Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.
    Author: Julià E, Montalban X, Al-Zayat H, Issazadeh-Navikas S, Goertsches R, Martin R, Comabella M.
    Journal: J Neuroimmunol; 2006 Nov; 180(1-2):147-58. PubMed ID: 16899302.
    Abstract:
    OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
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