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  • Title: Treatment of proliferative lupus nephritis: a changing landscape.
    Author: Adu D.
    Journal: Kidney Int; 2006 Aug; 70(4):616-8. PubMed ID: 16900218.
    Abstract:
    Grootscholten et al. report a randomized controlled trial comparing azathioprine plus intravenous methylprednisolone and oral prednisolone (AZA group) with intermittent intravenous cyclophosphamide and oral prednisolone (CY group) in patients with proliferative lupus nephritis. AZA-treated patients were more likely to develop non-sustained doubling of their serum creatinine, although not significantly so, and significantly more likely to have a relapse of their nephritis than CY-treated patients.
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