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  • Title: Total synthesis of (+)-hygrine via asymmetric phase-transfer catalytic alkylation.
    Author: Lee JH, Jeong BS, Ku JM, Jew SS, Park HG.
    Journal: J Org Chem; 2006 Aug 18; 71(17):6690-2. PubMed ID: 16901174.
    Abstract:
    The first enantioselective synthesis of (+)-hygrine (1) is reported. 1 was obtained in 12 steps with 29% overall yield and 97% ee via asymmetric phase-transfer catalytic alkylation and ring-closing metathesis as key steps. The absolute configuration of (+)-hygrine could be directly confirmed as R.
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