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  • Title: Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
    Author: Mante S, Minneman KP.
    Journal: Eur J Pharmacol; 1990 Jan 10; 175(2):203-5. PubMed ID: 1690138.
    Abstract:
    Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.
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