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  • Title: Effect of 1-deamino 8-D-arginine vasopressin spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis.
    Author: Akoğlu E, Görür S, Atik E, Okuyucu S, Sangün O.
    Journal: Int J Pediatr Otorhinolaryngol; 2006 Nov; 70(11):1919-22. PubMed ID: 16901550.
    Abstract:
    OBJECTIVE: To determine any possible adverse effect of 1-deamino 8-D-arginine vasopressin (DDAVP) spray on nasal cytology and mucociliary clearance in patients with nocturnal enuresis. METHODS: Twenty-two children aged 6-16 enrolled in the study. Epithelial surface cells samples were taken from the nasal mucosa and mucociliary clearance time was calculated before and 1 and 6 months after administration of DDAVP spray. RESULTS: No qualitative changes in the epithelial surface cells and mucociliary clearance time were observed at 1 and 6 months after therapy. CONCLUSION: Based on the findings of the present study, DDAVP spray can be used for 6 months in children without apparent risk of damage to the epithelial surface cells and mucociliary clearance time.
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