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  • Title: Synthesis and antiviral evaluation of novel 5'-norcarboacyclic phosphonic acid nucleosides.
    Author: Kim A, Hong JH.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2006; 25(8):941-50. PubMed ID: 16901824.
    Abstract:
    This article describes a very simple route for synthesizing a novel 5'-norcarboacyclic nucleotides. The condensation of the mesylates 17 and 18 with the natural nucleosidic bases (A,U,T,C) under standard nucleophilic substitution (K2CO3, 18-Crown-6, DMF) and deprotection afforded the target nucleotide analogues 27-34. In addition, these compounds were evaluated for their antiviral properties against various viruses.
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