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  • Title: HLA-DR, DQ and DP antigen expression in synovial fluid T lymphocytes in rheumatoid arthritis: cell cycle analysis of HLA-DP positive T cells.
    Author: Hirose T, Goto M, Okumura K.
    Journal: J Rheumatol; 1990 Jan; 17(1):18-23. PubMed ID: 1690301.
    Abstract:
    Cell surface expression of HLA-DR, DQ and DP antigens on synovial fluid (SF) T cells was analyzed in 43 patients with rheumatoid arthritis. Marked increase in the positive expression of all 3 Ia antigens was observed in the SF T cells compared to the counterpart, peripheral blood T cells. Both the DNA and RNA content of HLA-DP+ T cells were analyzed using acridine orange stain. RNA content in the HLA-DP+ SF T cells increased in comparison to that in the HLA-DP- SF T cells or normal peripheral blood T cells. Our findings suggest that majority of the SF T cells are activated and express HLA-DP antigen, while not proliferating.
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