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  • Title: Novel benzimidazole-based MCH R1 antagonists.
    Author: Carpenter AJ, Al-Barazanji KA, Barvian KK, Bishop MJ, Britt CS, Cooper JP, Goetz AS, Grizzle MK, Hertzog DL, Ignar DM, Morgan RO, Peckham GE, Speake JD, Swain WR.
    Journal: Bioorg Med Chem Lett; 2006 Oct 01; 16(19):4994-5000. PubMed ID: 16904318.
    Abstract:
    The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
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