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  • Title: Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.
    Author: Nam SJ, Ko H, Shin M, Ham J, Chin J, Kim Y, Kim H, Shin K, Choi H, Kang H.
    Journal: Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5398-402. PubMed ID: 16905319.
    Abstract:
    Three novel (1-3) and two known (4-5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.
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