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  • Title: Genetic and environmental factors affecting self-rated health from age 16-25: a longitudinal study of Finnish twins.
    Author: Silventoinen K, Posthuma D, Lahelma E, Rose RJ, Kaprio J.
    Journal: Behav Genet; 2007 Mar; 37(2):326-33. PubMed ID: 16906466.
    Abstract:
    We analyzed genetic and environmental determinants of self-rated health and its change from adolescence to early adulthood. Questionnaires were mailed to Finnish twins born 1975-1979 at ages 16, 17, 18 1/2 and, on average, 25 years of age (N=2465 complete twin pairs). The data were analyzed using quantitative genetic methods for twin data by the Mx statistical package. Heritability of self-rated health was greatest at age 16 (63%, 95% confidence intervals (CI) 56-67%, men and women together) and declined steadily to age 25 (33%, 95% CI 25-41%). The residual variation was due to unshared environments. Health ratings at different ages were modestly correlated (r=0.33-0.61). These correlations were mainly due to genetic factors, but unshared environment also contributed to them. An important challenge for further research is to identify environmental influences contributing to self-rated health independently of, or in interaction with, genetic factors.
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