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  • Title: Antiplasmodial activity of Homalium letestui.
    Author: Okokon JE, Ita B, Udokpoh AE.
    Journal: Phytother Res; 2006 Nov; 20(11):949-51. PubMed ID: 16906638.
    Abstract:
    The in vivo antiplasmodial activity of the ethanol root extract of Homalium letestui used as a malaria remedy in Southern Nigeria was evaluated in Plasmodium berghei berghei infected mice. Homalium letestui root extract (500-1000 mg/kg/day) exhibited significant (p < 0.05) blood schizontocidal activities both in a 4-day early infection test and in an established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The root extract possesses significant (p < 0.05) antiplasmodial activity, which can be exploited in malaria therapy.
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