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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
    Author: Lau JF, Jeppesen CB, Rimvall K, Hohlweg R.
    Journal: Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5303-8. PubMed ID: 16908150.
    Abstract:
    A group of tri and tetrasubstituted urea derivatives have been found to be hH(3)-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.
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