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  • Title: [Damage to the structure of DNA and to the metabolism of nucleic acids in the thymus in relation to the dose of tritium oxide].
    Author: Shorokhova VB, Rusinova GG, Mushkacheva GS.
    Journal: Med Radiol (Mosk); 1990 Mar; 35(3):21-3. PubMed ID: 1690836.
    Abstract:
    Single administration of tritium oxide (1.1-44 MBq per 1 kg of body mass) causes a dose-dependent decrease in the level of rat thymus nucleic acids within the range of concentrations of injected tritium 5.5-44 MBq/g. Biosynthesis of nucleic acids turned out to be more sensitive to tritium oxide action. The rate of biosynthesis changed on the 1st day at the lowest dose of 1.1 MBq/g, the absorbed dose on the 1st day was 7.5 cGy. Dose-dependent disorders of DNA structure in the content of 2-strand DNA after the administration of tritium oxide (9-44 MBq/g) were established.
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