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  • Title: Double cancer of gall bladder and bile duct not associated with anomalous junction of the pancreaticobiliary duct system.
    Author: Hori H, Ajiki T, Fujita T, Okazaki T, Suzuki Y, Kuroda Y, Fujimori T.
    Journal: Jpn J Clin Oncol; 2006 Oct; 36(10):638-42. PubMed ID: 16908513.
    Abstract:
    BACKGROUND: Simultaneous double cancers of the biliary tract are rare. Most of them are thought to be associated with pancreaticobiliary maljunction (PBM); however, the characteristics of tumours without PBM are still unclear. METHODS: Histology, immunoreactivity with carcinoembryonic antigen, carbohydrate antigen 19-9 and p53 and mutations in the K-ras gene were examined in tumours resected from cases of simultaneous double cancers of the biliary tract. RESULTS: Four cases of simultaneous double cancers of the biliary tract were identified among 108 patients with biliary tract cancer (3.7%). None of the four cases associated with PBM, and the results of histological, immunohistochemical and genetic examinations differed between the bile duct and gall bladder cancers in each case. CONCLUSION: Even when they do not associate with PBM, double cancers in the biliary tract are more likely to be the result of multicentric development.
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