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  • Title: Evaluation of different antibiotic actions combined with rifampicin. In vitro synergism against Pseudomonas and Proteus.
    Author: Urena MT, Barasoain I, Espinosa M, Garcia E, Portoles A.
    Journal: Chemotherapy; 1975; 21(2):82-9. PubMed ID: 169107.
    Abstract:
    Associations of penicillin, streptomycin, tetracycline and polymyxin B with rifampicin were tested for synergism against Pseudomonas and Proteus pathological strains. The combination of rifampicin and polymyxin B was clearly synergistic for all strains as it was evaluated by isobolograms and killing curvesmthe bactericidal action of this association, without any cross-resistance between its components, may eradicate gram-negative bacteria infections with marked polyvalent drug resistances.
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