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  • Title: SHV-5 extended-spectrum beta-lactamases in clinical isolates of Escherichia coli in Malaysia.
    Author: Subramaniam G, Palasubramaniam S, Navaratnam P.
    Journal: Indian J Med Microbiol; 2006 Jul; 24(3):205-7. PubMed ID: 16912441.
    Abstract:
    Escherichia coli isolates resistant to ceftazidime isolated in the University Malaya Medical Center (UMMC) Kuala Lumpur, Malaysia, between the years 1998 and 2000 were studied for extended-spectrum beta-lactamase (ESBL) production. All strains were analysed phenotypically and genotypically and found to be ESBL-producing organisms harbouring SHV-5 beta-lactamase. This was confirmed by PCR-SSCP and nucleotide sequencing of the blaSHV amplified gene. As there was no evidence of ESBL activity in E. coli prior to this, coupled with the fact that there was a predominance of SHV-5 beta-lactamases in Klebsiella pneumoniae isolates in UMMC, we postulate that the E. coli obtained the SHV-5 beta-lactamase genes by plasmid transfer from the ESBL-producing K. pneumoniae.
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