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  • Title: Characterization of HNK-1 bearing glycoproteins in human peripheral nerve myelin.
    Author: van den Berg LH, Sadiq SA, Thomas FP, Latov N.
    Journal: J Neurosci Res; 1990 Mar; 25(3):295-9. PubMed ID: 1691305.
    Abstract:
    The HNK-1 carbohydrate epitope, which is shared by several members of the immunoglobulin gene super-family, is also the target epitope for IgM anti-MAG autoantibodies in patients with demyelinating neuropathy. By Western blot analysis, there are 7 HNK-1 immunoreactive glycoproteins in human peripheral nerve myelin, two of which have previously been identified as the myelin associated glycoprotein (MAG) and the P0 glycoprotein. In this study, the remaining HNK-1 bearing glycoprotein bands were characterized by immunoblot and NH2-terminal sequence analysis, and were all identified as degradation products or aggregates of the Po glycoprotein. MAG and P0 are therefore the only HNK-1 bearing glycoproteins in human peripheral nerve myelin.
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