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  • Title: [Mechanism of myocardial cell apoptosis during delayed preconditioning induced by Sini decoction].
    Author: Liu Y, Chen C, Wu WK, Duan XF.
    Journal: Zhong Yao Cai; 2006 Apr; 29(4):345-8. PubMed ID: 16913489.
    Abstract:
    OBJECTIVE: The present study was designed to determine the mechanism of myocardial cell apoptosis during delayed preconditioning induced by Sini decoction (SND). METHODS: Sprage-Dawleytrats were divide into four groups: control, sham, I/R and SND groups. Left anterior descending coronary artery (LAD) of the rats in I/R group were occluded for h and reperfused for h. SND group rates were pretreated with Sini decoction (5 g x kg(-1) x d(-1)) for three days and the last treatment was pretreated 24h before the index occlusion. Cell apoptosis was measured by flow cytometry, mRNA level of bcl-xl/bcl-xs was detected by RT-PCR and apoptosis inducing factor (AIF) was detected by western blotting. RESULTS: SND pretreatment for 24 hours could decrease cell apoptosis, increase bcl-xl-bcl-xs mRNA ratio and decrease release of AIF from mitochondria. CONCLUSION: The delayed preconditioning induced by SND can decrease myocardial cell apoptosis. The mechanism is related to mitochondria protection.
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