These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Anti-HIV-1 effect of compound K3 from flower of Japanese pagoda tree in vitro].
    Author: Zhang GH, Zheng YT.
    Journal: Zhong Yao Cai; 2006 Apr; 29(4):355-8. PubMed ID: 16913492.
    Abstract:
    OBJECTIVE: To investigate the anti-HIV properties of compound K3 purified from Japanese pagoda tree flower as well as its anti-HIV mechanism in vitro. METHODS: The cytotoxicity of compound K3 was detected by MTF assay. The anti-HIV activities was measured by syncytium reduction, p24 antigen production and protection for HIV-1 induced cytopathic effects in various HIV-1 strains acute or chronically infected cells system. The mechanism of action of the compound K3 was determined by inhibiting HIV-1 RT activity, cell-to-cell fusion, virus binding and entry into cells. CONCLUSION: Compound K3 is found to be a potent inhibitor of HIV-1 replication against a various viruses in different cells including laboratory strain (HIV-1 (IIIB)), drug-resistant (HIV-1(74V)) and clinical isolates (HIV-1 (KM018)) of HIV-1. It indicats that K3 act through at least two clarified antiviral mechanisms: inhibition of HIV-1 entry into cell and inhibition of HIV-1 RT activity.
    [Abstract] [Full Text] [Related] [New Search]