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  • Title: Susceptibility of red blood cell lipids to in vitro oxidation and antioxidant status in preeclampsia.
    Author: Dirican M, Safak O, Uncu G, Sarandöl E.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2008 Oct; 140(2):158-64. PubMed ID: 16914260.
    Abstract:
    OBJECTIVE: To investigate susceptibility of red blood cell (RBC) lipids to oxidation and antioxidant status in preeclampsia. STUDY DESIGN: Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 healthy pregnant women were included in this cross-sectional study. Susceptibility of RBC to oxidative stress was determined by measuring RBC-malondialdehyde levels after incubation with hydrogen peroxide. Vitamins E and C, total carotenoids and erythrocyte superoxide dismutase and glutathione peroxidase (GPx) activities and serum total antioxidant capacity (TAC) were determined spectrophotometrically. One-way analysis of variance and correlation analysis were used for statistical analyses. RESULTS: Compared with the normal pregnant women, susceptibility of RBC to oxidation was enhanced in the mild (p<0.05) and severe (p<0.01) preeclampsia groups, TAC was lower in the mild (p<0.01) and severe (p<0.001) preeclampsia groups. Vitamin C level was decreased in severe preeclampsia and total carotene level was decreased in mild and severe preeclampsia groups (p<0.05). GPx activity was also decreased in the mild (p<0.01) and severe (p<0.05) preeclampsia groups. CONCLUSION: The results of the present study supported the oxidative stress hypothesis of preeclampsia and it is possible that RBC play a role in the pathophysiology of the disease.
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