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  • Title: Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilation.
    Author: Dayer MJ, Jonville S, Chatwin M, Swallow EB, Porcher R, Sharshar T, Ross ET, Hopkinson NS, Moxham J, Polkey MI.
    Journal: Respir Physiol Neurobiol; 2007 Mar 15; 155(3):243-54. PubMed ID: 16914394.
    Abstract:
    Whole body exercise is followed by a depression of the diaphragm motor evoked potential (MEP). It is unknown whether the change is due to diaphragm activity or whole body exercise. To test the hypothesis that exercise-induced MEP depression was related to diaphragm activity, we performed two experiments. The first examined the effect of whole body exercise, performed with and without the use of non-invasive ventilation (NIV). NIV resulted in significant unloading of the diaphragm (pressure time product 101+/-68 cm H(2)O/s/min versus 278+/-95 cm H(2)O/s/min, p<0.001). Both conditions produced significant MEP depression compared to the control condition (% drop at 5 min, after exercise and exercise with NIV: 29 and 34%, p=0.77). Study 2 compared exercise with isocapnic hyperventilation. At 20 min the MEP had fallen by 29% in the exercise session versus 5% with hyperventilation (p=0.098). We conclude that the work of breathing during whole body exercise is not the primary driver of exercise-induced diaphragm MEP depression.
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