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  • Title: Prolonged radioprotective activity of WR-2721 linked to dextran.
    Author: Mönig H, Sedlmeier H, Oehlert W, Konermann G, Messerschmidt O.
    Journal: Strahlenther Onkol; 1990 Mar; 166(3):235-41. PubMed ID: 1691532.
    Abstract:
    The radioprotective agent WR-2721 was linked to dextran and poly(glutamic acid) respectively, to obtain a prolonged radioprotective ability. Male mice were administered these water soluble polymer conjugates one to 72 hours prior to a whole body irradiation with X-rays. A prolongation of radioprotective efficiency was achieved with two dextran-(WR-2721)-conjugates. For a period of 24 hours between administration, and irradiation dose reduction factors of 1.14 +/- 0.04 and 1.10 +/- 0.03 respectively were found. After 72 hours, no protective effect was observed. Histopathological investigations of the liver for formation of tumors 200 to 600 days after irradiation seems to indicate that a protective effect is not produced by the dextran-(WR-2721)-conjugates.
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