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  • Title: [The anti-arrhythmia action of combinations of N-propylajmaline bromide with anti-arrhythmia agents of different classes].
    Author: Gendenshteĭn EI, Balashov VP, Kostin IaV, Oleĭnikov VE.
    Journal: Farmakol Toksikol; 1990; 53(1):30-2. PubMed ID: 1691716.
    Abstract:
    In experiments on 68 dogs with ventricular arrhythmia at the late stage of experimental myocardial infarction caused by the coronary artery branch occlusion it was shown that combinations of N-propylaimaline bromide (IA class of antiarrhythmic agents) with trimecaine (IB class) or anapriline (II class) or phynoptine (IV class) induce a significant increase of the antiarrhythmic effect that is not observed at combination of N-propylaimaline with ethmosine (the both antiarrhythmic drugs belong to IA class). This potentiating effect is thought to be related to differences in the molecular mechanisms of action of antiarrhythmic drugs.
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