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  • Title: Paroxysmal nocturnal hemoglobinuria and decay-accelerating factor.
    Author: Rosse WF.
    Journal: Annu Rev Med; 1990; 41():431-6. PubMed ID: 1691902.
    Abstract:
    The blood cells in paroxysmal nocturnal hemoglobinuria (PNH) lack several proteins, including some that regulate the activation of complement on the cell surface. Decay-accelerating factor (DAF), the first such protein to be identified, is, like all the missing proteins, affixed to the membrane by a glycolipid anchor containing phosphotidylinositol, hexoses, and ethanolamine. The defect in PNH appears to be an inability to place or maintain proteins linked in this way on the cell surface.
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