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  • Title: Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds.
    Author: Mishra B, Priyadarsini KI, Mohan H, Mugesh G.
    Journal: Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5334-8. PubMed ID: 16919452.
    Abstract:
    Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride (EbTe(2)) with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of EbTe(2), the inhibitory effect on gamma-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of EbTe(2).
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