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  • Title: Pharmacological properties of rhamnose-rich polysaccharides, potential interest in age-dependent alterations of connectives tissues.
    Author: Andrès E, Molinari J, Péterszegi G, Mariko B, Ruszova E, Velebny V, Faury G, Robert L.
    Journal: Pathol Biol (Paris); 2006 Sep; 54(7):420-5. PubMed ID: 16919895.
    Abstract:
    Rhamnose-rich oligo- and polysaccharides (RROPs) were tested for their potential pharmacological properties using human skin fibroblasts in serial cultures. The substances tested were shown to stimulate cell proliferation, decrease elastase-type activity, stimulate collagen biosynthesis, and protect hyaluronan against free radical mediated degradation. These reactions appear to be triggered by the mediation of a specific alpha-L-rhamnose recognizing lectin-site acting as a receptor, transmitting signals to the cell-interior. The rapid increase of intracellular free calcium after addition of RROP-1 and preliminary data using micro arrays appear also to confirm this contention.
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