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  • Title: [Effects of SP1-11 and its N-terminal fragment SP1-4 on several indices of the microcirculatory system in stress].
    Author: Gorizontova MP, Speranskaia TV, Oeme P, Odariuk Iu.
    Journal: Biull Eksp Biol Med; 1990 Jan; 109(1):25-7. PubMed ID: 1692245.
    Abstract:
    In the experiments on rats it was shown that 5-hour immobilization induced the disturbances of terminal blood flow, degranulation of mast cells, increase of venular permeability and contractile activity of lymphaticus. I/p injection SP1-11 (125 micrograms/kg) before stress aggravated the disturbances caused by immobilization. The prophylactic i/p injection SP1-4 induced tranquilizing (100%), sedative (30%) or narcosis (20%) effect. In the rats with sedative or narcosis effects the relative normalization of components of microcirculatory system was observed.
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