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  • Title: Hippocampal kindling leads to motor map expansion.
    Author: van Rooyen F, Young NA, Larson SE, Teskey GC.
    Journal: Epilepsia; 2006 Aug; 47(8):1383-91. PubMed ID: 16922885.
    Abstract:
    PURPOSE: To determine whether seizure activity, repeatedly elicited in the hippocampus, could alter the functional organization of neocortical movement representations (motor maps) and whether a relation exists between the number of afterdischarges recorded in the sensorimotor neocortex and the size of the motor maps. METHODS: We electrically kindled the right ventral hippocampus of Long-Evans hooded rats, twice daily, for 40 sessions and recorded the afterdischarges in the stimulated hippocampus and right sensorimotor neocortex. Between 3 and 7 days after the last seizure, we used high-resolution intracortical microstimulation to derive the forelimb-movement representations in the left (un-implanted) sensorimotor neocortex. RESULTS: In the hippocampal kindled rats, we observed a dramatic expansion of the area of neocortex that would elicit forelimb movements compared with sham-kindled controls. The number of afterdischarges recorded in the neocortex was significantly and positively correlated with the size of the motor maps. CONCLUSIONS: Seizures propagating from the hippocampus have long-distance effects on the functional organization of motor maps.
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