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  • Title: EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment.
    Author: Chim CS, Pang YY, Ooi GC, Mok MY, Shek TW.
    Journal: Haematologica; 2006 Aug; 91(8 Suppl):ECR31. PubMed ID: 16923515.
    Abstract:
    A patient with longstanding rheumatoid arthritis (RA) developed swelling in a chronically inflamed knee joint while receiving prolonged methotrexate treatment. Magnetic resonance imaging and positron-emission tomography showed soft tissue swelling with intense tracer uptake. Biopsy confirmed high-grade B-cell lymphoma. He developed complete remission with rituximab plus CEOP. The role of chronic inflammation and methotrexate in the pathogenesis of lymphoma in RA was discussed.
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