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  • Title: CSF BACE1 activity is increased in CJD and Alzheimer disease versus [corrected] other dementias.
    Author: Holsinger RM, Lee JS, Boyd A, Masters CL, Collins SJ.
    Journal: Neurology; 2006 Aug 22; 67(4):710-2. PubMed ID: 16924032.
    Abstract:
    To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
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