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  • Title: Immunological effects of recombinant feline interferon-omega (KT-80) administration in the dog.
    Author: Kuwabara M, Nariai Y, Horiuchi Y, Nakajima Y, Yamaguchi Y, Horioka E, Kawanabe M, Kubo T, Yukawa M, Sakai T.
    Journal: Microbiol Immunol; 2006; 50(8):637-41. PubMed ID: 16924149.
    Abstract:
    The immunological effects of recombinant feline interferon-omega (rFeIFN-omega ; KT-80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT-80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post-administration survived. These results suggest that rFeIFN-omega (KT-80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement.
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