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  • Title: Intravesical mitomycin C for superficial transitional cell carcinoma.
    Author: Bolenz C, Cao Y, Arancibia MF, Trojan L, Alken P, Michel MS.
    Journal: Expert Rev Anticancer Ther; 2006 Aug; 6(8):1273-82. PubMed ID: 16925493.
    Abstract:
    Intravesical instillation of mitomycin C after a transurethral resection of a bladder tumor constitutes a standard treatment modality in the management of superficial transitional cell carcinoma in the urinary bladder. An immediate instillation of mitomycin C after transurethral resection has been shown to reduce the recurrence rate of superficial transitional cell carcinoma. Intravesical mitomycin C is generally considered to be a safe treatment option, but the past few years have seen the publication of a number of case reports on severe complications following mitomycin C instillation. This article reports on the mode of action, as well as the intravesical effects and current indications for mitomycin C instillation. This review will summarize the oncological benefits of mitomycin C in comparison with other intravesical treatments, such as bacillus Calmette-Guérin, and elucidate the incidence and types of possible complications associated with intravesical mitomycin C chemotherapy.
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