These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tracheal organ cultures as a useful tool to study Felid herpesvirus 1 infection in respiratory epithelium.
    Author: Leeming G, Meli ML, Cripps P, Vaughan-Thomas A, Lutz H, Gaskell R, Kipar A.
    Journal: J Virol Methods; 2006 Dec; 138(1-2):191-5. PubMed ID: 16926054.
    Abstract:
    Felid herpesvirus 1 (FeHV-1) is an important feline pathogen of the upper respiratory tract which can be identified in clinical cases by virus isolation and PCR. Studies on the effect and mode of spread of FeHV-1 in the respiratory epithelium, however, have previously only been performed in infected cats. Feline tracheal organ cultures which were inoculated with FeHV-1 at varying multiplicity of infection (MOI) were established. A dose-dependent response was observed. Low MOIs induced multifocal infection in the otherwise viable respiratory epithelium, which allowed monitoring of viral growth over several days. Therefore, tracheal organ cultures represent a suitable model for further study of the morphological and functional effects of FeHV-1 on respiratory epithelium, mimicking the in vivo situation.
    [Abstract] [Full Text] [Related] [New Search]