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  • Title: Autoimmune thrombocytopenia induced by PEG-IFN-alpha plus ribavirin in hepatitis C.
    Author: Demirturk N, Cevik F, Demirdal T, Aykin N, Aslan V.
    Journal: Platelets; 2006 Aug; 17(5):340-3. PubMed ID: 16928608.
    Abstract:
    Mild thrombocytopenia is a common adverse effect of interferon-alpha and pegylated interferon-alpha, largely ascribed to bone marrow suppression. Nevertheless, rare cases of autoimmune thrombocytopenia following standard or pegylated interferon treatment have been reported in the literature. In this report, we have presented a patient who developed an immune-mediated thrombocytopenia during the course of therapy with pegylated interferon/ribavirin for hepatitis C virus infection. After cessation of pegylated interferon/ribavirin treatment, thrombocytopenia was treated successfully with danazol and intravenous gamma-globulin.
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