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  • Title: A case of early onset normotensive scleroderma renal crisis in a patient with diffuse cutaneous systemic sclerosis.
    Author: Bashandy HG, Javillo JS, Gambert SR.
    Journal: South Med J; 2006 Aug; 99(8):870-2. PubMed ID: 16929883.
    Abstract:
    Scleroderma renal crisis (SRC) has classically been defined as a new onset of accelerated arterial hypertension associated with a rapid increase in serum creatinine concentration and/or microangiopathic hemolytic anemia. SRC occurs in approximately 20% of patients with systemic sclerosis who have diffuse cutaneous manifestations. In addition, 10% of reported cases of SRC with diffuse cutaneous involvement have normal blood pressures; in the majority of these cases, SRC occurs after treatment with corticosteroids. We describe a patient who presented with an early onset SRC in the setting of diffuse cutaneous systemic sclerosis in evolution without prior accelerated arterial hypertension or corticosteroid use.
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