These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Holothurin: an activator of bovine brain 3'-5' phosphodiesterase.
    Author: Vig PJ, Mehrotra BD, Desaiah D.
    Journal: Res Commun Chem Pathol Pharmacol; 1990 Mar; 67(3):419-22. PubMed ID: 1693008.
    Abstract:
    The effect of marine toxin, holothurin A, on calmodulin(CaM)-dependent bovine brain 3'-5' phosphodiesterase (PDE) was studied. Holothurin stimulated CaM-depleted PDE in a concentration dependent manner and this interaction was independent of Ca2+ concentrations. Activation of PDE by holothurin was pH and incubation temperature dependent. Heat treatment of holothurin (at 95 degrees C) at various time intervals (2-8 min) decreased its ability to stimulate PDE. CaM-dependent dependent PDE activity was decreased by holothurin. CaM antagonist W-7 and an organochlorine compound chlordecone significantly inhibited holothurin stimulated PDE. These data indicate that holothurin activates CaM-deficient 3'-5' PDE which is antagonized by classical CaM antagonists.
    [Abstract] [Full Text] [Related] [New Search]