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  • Title: [Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil].
    Author: Silaeva SA, Khatsernova BIa, Golenchenko VA, Berchenko GN, Nikolaev AIa, Shekhter AB.
    Journal: Vopr Med Khim; 1990; 36(1):82-4. PubMed ID: 1693022.
    Abstract:
    Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.
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