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  • Title: Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma.
    Author: Li FQ, Xu S, Su H, Deng JX, Liu JY, Hu JH.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Feb 01; 846(1-2):319-22. PubMed ID: 16931190.
    Abstract:
    A gradient reversed-phase HPLC assay has been developed to determine sodium ferulate (SF) in beagle dog plasma with tinidazole as an internal standard. Chromatographic separation was made on a C(18) column using 0.5% acetic acid and acetonitrile (80:20, v/v) as mobile phase. UV detection was performed at 320 nm. The calibration curve for SF was linear in the range of 0.05-10 microg/ml, and the achieved limit of quantification (LOQ) was 51.4 ng/ml. The results of linearity, within- and between-day precision, and accuracy demonstrate that this method is reliable, sensitive and sufficient for in vivo beagle dog pharmacokinetic (PK) studies of SF.
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