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  • Title: Anatomical correlates of early mutism in progressive nonfluent aphasia.
    Author: Gorno-Tempini ML, Ogar JM, Brambati SM, Wang P, Jeong JH, Rankin KP, Dronkers NF, Miller BL.
    Journal: Neurology; 2006 Nov 28; 67(10):1849-51. PubMed ID: 16931509.
    Abstract:
    Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.
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