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  • Title: Wernicke's encephalopathy: beyond alcoholism.
    Author: Wilson RK, Kuncl RW, Corse AM.
    Journal: Nat Clin Pract Neurol; 2006 Jan; 2(1):54-8; quiz 58. PubMed ID: 16932521.
    Abstract:
    BACKGROUND: A 17-year-old pregnant woman presented to hospital at 19 weeks' gestation with an 8-week history of hyperemesis gravidarum, 16.8 kg of weight loss, and new-onset weakness, dizziness and blurred vision. Examination of the patient showed confusion, papilledema, ophthalmoparesis, nystagmus, reduced hearing and truncal ataxia. INVESTIGATIONS: Physical examination, abdominal ultrasound, fetal ultrasound, brain MRI, magnetic resonance angiography, magnetic resonance venography and cerebrospinal-fluid analysis. DIAGNOSIS: Wernicke's encephalopathy, hyperemesis gravidarum and fetal loss. MANAGEMENT: Intravenous thiamine repletion and elimination of deficiency risk factors.
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