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  • Title: Hydroxylation of collagen by lungs of rats administered bleomycin.
    Author: Last JA, Gerriets JE, Armstrong LC, Gelzleichter TR, Reiser KM.
    Journal: Am J Respir Cell Mol Biol; 1990 Jun; 2(6):543-8. PubMed ID: 1693282.
    Abstract:
    Collagen synthesized by tissue minces from lungs of rats administered 1 unit of bleomycin by intratracheal instillation 1 or 2 wk earlier contained relatively more hydroxylysine than did collagen made by lungs from saline-instilled control animals. Most, if not all, of the relative increase in lysine hydroxylation could be localized to the alpha 1 (I) chain of type I collagen. Lung homogenates from bleomycin-treated rats showed increased activity of lysyl hydroxylase (EC 1.14.11.4), the enzyme catalyzing the conversion of collagen-bound lysine to hydroxylysine. Thus, the increased hydroxylation of lysine and of lysine-derived cross-links previously observed in collagen of diseased human lungs and in animal models of lung fibrosis is reflected in an in vitro system.
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