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Title: Antiviral activity of substituted homoisoflavonoids on enteroviruses. Author: Tait S, Salvati AL, Desideri N, Fiore L. Journal: Antiviral Res; 2006 Dec; 72(3):252-5. PubMed ID: 16934879. Abstract: The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.[Abstract] [Full Text] [Related] [New Search]