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  • Title: A myelin basic protein antibody cascade in purified IgG from cerebrospinal fluid of multiple sclerosis patients.
    Author: Warren KG, Catz I.
    Journal: J Neurol Sci; 1990 Apr; 96(1):19-27. PubMed ID: 1693669.
    Abstract:
    Immunoglobulin G (IgG) was purified by affinity chromatography from the CSF of multiple sclerosis (MS) patients and controls. In MS patients, the IgG fraction contains anti-myelin basic protein (anti-MBP), anti-MBP neutralizing antibody and an antibody which inhibits neutralization of anti-MBP. Anti-MBP was detected in patients with acute relapses, anti-MBP neutralizing antibody was present in patients in clinical remission and the inhibiting antibody was detected in patients with chronically progressing MS. A myelin basic protein antibody cascade could be involved in the mechanism of MS.
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