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  • Title: Hemodynamic effects of calcium antagonists with high or low vascular selectivity.
    Author: Thorén P, Sjölander M, Nordlander M.
    Journal: J Cardiovasc Pharmacol; 1990; 15 Suppl 4():S21-4. PubMed ID: 1693719.
    Abstract:
    Infusion of felodipine and verapamil in increasing doses to anesthetized spontaneously hypertensive rats induced a progressive fall in arterial blood pressure (BP). To estimate the cardiac action of the different drugs, we also measured changes in cardiac output (CO) and velocity of flow (dF/dT) by a Doppler flow probe placed on the ascending aorta. Infusion of verapamil induced a parallel decrease in mean arterial BP, CO, and cardiac inotropy (as estimated by max. dF/dT). In contrast, upon felodipine administration, the decrease in arterial BP was accompanied by an initial small rise in dF/dT. A decrease in dF/dT was observed only after high doses of felodipine, which caused pronounced levels of hypotension.
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